Definition of "NSAID"

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NSAID are used for relieving pain, alleviating fever, and in higher doses, anti-inflammatory. They are non-narcotic, and thus can be used as a non-addictive alternative to narcotics. They are non-steroidal, but still have the anti-inflammatory action of steroids.


Non-selective COX inhibitor, and so therefore has the unwanted GI side effects due to inhibition of COX-1. This includes:

  • Salicylates, including:
    • Aspirin (see page)
    • Diflunisal
    • Salicylic acid and other salicylates
    • Salsalate
  • Propionic acid derivatives, including:
    • Ibuprofen, has some anti-platelet effect, although of shorter duration than aspirin (and other anti-platelets). Examples include Nurofen, AdvilNurofen Plus has added Codeine phosphate

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    • Dexibuprofen
    • Naproxen
    • Fenoprofen
    • Ketoprofen
    • Dexketoprofen
    • Flurbiprofen
    • Oxaprozin
    • Loxoprofen
  • Acetic acid derivatives, including:
    • Indometacin (Indocid)
    • Tolmetin
    • Sulindac
    • Etodolac
    • Ketorolac
    • Diclofenac (Voltaren)
    • Aceclofenac
    • Nabumetone
  • Enolic acid (Oxicam) derivatives, including:
    • Piroxicam
    • Meloxicam (Mobic)
    • Tenoxicam
    • Droxicam
    • Lornoxicam
    • Isoxicam
    • Phenylbutazone
  • Anthranilic acid derivatives (Fenamates), including:
    • Mefenamic acid
    • Meclofenamic acid
    • Flufenamic acid
    • Tolfenamic acid
  • Selective COX-2 inhibitors (Coxibs), including:
    • Celecoxib (Celebrex)
    • Rofecoxib
    • Valdecoxib
    • Parecoxib
    • Lumiracoxib
    • Etoricoxib
    • Firocoxib
  • Sulfonanilides, including:
    • Nimesulide
  • Others, including:
    • Clonixin
    • Licofelone
Side effects
  • GI ulcers, and bleeding; hence, COX-2 inhibitors may be preferred
  • In kids, Reye's syndrome (i.e. fatal syndrome detrimenting brain, liver, hypoglycemia), so is only indicated in rheumatic fever and Kawasaki disease
  • Absolute:
    • Peptic ulcer or stomach bleeding
    • Uncontrolled HTN
    • Kidney disease
    • Past TIA (excluding aspirin)
    • Past stroke (excluding aspirin)
    • Past MI (exclusin aspirin)
    • CAD (excluding aspirin)
    • Undergoing CABG
    • Taking aspirin for heart
    • In 3rd trimester of pregnancy
    • Pt's who have undergone gastric bypass
    • Pt's who have a Hx of allergic or allergic-type NSAID hypersensitivity reactions, e.g. aspirin-induced asthma
  • Relative:
    • Irritable bowel syndrome
    • Pt's >50yo, who have a FH of GI problems
    • Pt's who have had past GI problems from NSAID use
See also

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Definition of NSAID | Autoprac

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