Definition of "Nephritic syndrome"

Last modified: about 1 month

Nephritic syndrome is a glomerular disorder, causing proteinuria and hematuria.

  • Hematuria (blood in urine)
  • Proteinuria (protein in urine)
  • HTN
  • Blurred vision
  • Azotemia
  • Oliguria (low urine output <400mL/day)
  • Caused by inflammation of the glomerulus
  • Characterized by a thin glomerular basement membrane, and small pores on the glomerulus, large enough to permit proteins (proteinuria) and RBC's (hematuria) to pass into the urine
  • Because of the proteinuria component, may involve hypoalbuminemia, due to albumin moving from blood into urine

Can be infectious, autoimmune, or thrombotic, and includes:

  • Children/adolescents:
    • IgA nephropathy
    • Post-streptococcal glomerulonephritis
    • Hemolytic uremic syndrome
    • Henoch-Schoenlein purpura
  • Adults:
    • Goodpasture syndrome
    • SLE
    • Rapidly progressing glomerulonephritis
    • Infective endocarditis
  • Although hematuria can be caused by bleeding anywhere in the urinary tract, if RBC's are trapped in urinary/RBC casts (i.e. strongly indicative of glomerular damage), bleeding likely originated in the nephron, and nephritic syndrome is probable
  • Anti-HTN
  • Anti-inflammatory
  • Reduction in potassium and salt
  • Physical rest
  • Depends on underlying etiology, as it isn't a disease
  • Prognosis in kids due to post-strep glomerulonephritis is good
See also
  • Nephrotic syndrome (only proteinuria, no hematuria)

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Definition of Nephritic syndrome | Autoprac

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