Antipsychotics are used to Tx psychosis, in particular, schizophrenia. They can also be used to Tx acute mania, agitation, bipolar disorder, autism, major depressive disorder, and so forth.

Both generations block receptors in the brain's dopaminergic pathways

Typical antipsychotics (aka 1st generation antipsychotics) are more likely to cause extrapyramidal symptoms, including Parkinsonian type movements, body rigidity, and involuntary tremors. It includes:

• Butyrophenones, including:
  • Benperidol
  • Bromperidol
  • Droperidol
  • Haloperidol (Haldol)

Source: 2010/02/haloperidol-459x306.jpg">Kern Pharma

• • Timiperone
  • Moperone (discontinued)
  • Pimamperone (discontinued)
• Diphenylbutylpiperidine, including:
  • Fluspirilene
  • Penfluridol
  • Pimozide
• Phenothiazines, including:
  • Acepromazine
  • Chlorpromazine
  • Cyamemazine
  • Dixyrazine
  • Fluphenazine
  • Levomepromazine
  • Perazine
  • Pericyazine
  • Perphenazine
  • Pipotiazine
  • Prochlorperazine
  • Promethazine
  • Prothipendyl
  • Thioproperazine (only available in Canada)
  • Trifluoperazine
  • Mesoridazine (discontinued)
  • Promazine (discontinued)
  • Thioridazine (discontinued)
  • Triflupromazine (discontinued)
• Thioxanthenes, including:
  • Chlorprothixene
  • Clopenthixol
  • Flupentixol
  • Thiothixene
  • Zuclopenthixol
• Others, including:
  • Clotiapine
  • Loxapine
  • Prothipendyl

In contrast, atypical antipsychotics (aka 2nd generation antipsychotics) have less extrapyramidal effect. Examples of atypical antipsychotics are:

• Amisulpride
• Amoxapine
• Aripiprazole
• Asenapine
• Cariprazine
• Clozapine

Source: ServIMG

• Blonanserin
• Iloperidone
• Lurasidone
• Melperone
• Nemonapride
• Olanzapine (Zyprexa, or in combination with the SSRI fluoxetine is known as Symbyax)

Source: GPW Law

Source: PSIC of Armacos

• Paliperidone
• Perospirone
• Quetiapine (Seroquel)

Source: Schmidt and Clark

• Remoxipride
• Risperidone (Risperdal)

Source: 2012/02/imgname-first_generic_risperdal_risperidone_fdaapproved-50226711-Risperdal1.jpg">CCHR Int

• Sertindole
• Sultopride
• Trimipramine
• Ziprasidone
• Zotepine

• Antidepressants
• Neuroleptic malignant syndrome