Definition of "Rh disease"

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Rh disease is a cause of hemolytic disease of the newborn.

Pathophysiology
  • During birth, the mother may be exposed to the infant's blood, causing the development of antibodies, which may affect the health of subsequent Rh+ pregnancies
  • It typically only occurs in a 2nd (or subsequent) pregnancy of Rh negative women, where the fetus' father is Rh positive, leading to a Rh+ pregnancy
Sx
  • Ranges from mild to severe
Complications
  • In mild cases, the fetus may have mild anemia with reticulocytosis
  • In moderate/severe cases, the fetus may have more marked anemia, and erythroblastosis fetalis (hemolytic disease of the newborn)
  • When very severe, it may cause hydrops fetalis, or stillbirth
Tx
  • Generally preventable by Tx the mother during pregnancy, or soon after delivery, with an IM injection of anti-RhD immunoglobulin (aka anti-D)
Paperwork
  • Information sheet regarding Rh factor and RhD immunization
  • Patient Rh (D) immunization consent form, including affixing the Pt label, Pt declaration that they have informed consent regarding the immunization, writing Printed name, Signature, and Date. Also, ticking whether they Consent or Decline the Routine antenatal immunization, Antenatal sensitizing event immunization, and Postnatal immunization, and according Printed name, Signature, and Date
  • Under Staff Use Only, there are 2 rows for Consent Provided, or Consent Declined, where if Provided, requires name, signature and date of midwife and M/O (medical officer). Or if declined, ticks for Routine antenatal Rh immunziation, Postnatal immunization, and Immunization following an antenatal sensitizing event, and again, requiring name, signature and ate of midwife and M/O
See also
  • Hemolytic disease of the newborn (category)

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Definition of Rh disease | Autoprac


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