Barbiturate are CNS depresants, that can produce a spectrum of effect.

• Allobarbital
• Amobarbital
• Aprobarbital
• Alphenal
• Barbital
• Brallobarbital
• Pentobarbital
• Phenobarbital (aka Phenobarbitone), a long-acting barbiturate, used widely as an antiepileptic medication

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• Secobarbital
• Sodium thiopental (thiopentone), an ultra-short acting barbiturate

• From mild sedation to total anesthesia
• Anxiolytics
• Hypnotics
• Anticonvulsants
• Analgesic effect, but these are somewhat weak, preventing it from being used in surgery

• Barbiturates are now largely replaced by benzodiazepines, because of their safer overdose profile
• However, it is still used for:
  • General anesthesia
  • Epilepsy
  • Tx of acute migraines and cluster headaches (under stringent protocols, and monitoring for addiction and abuse)
  • Assisted suicide and euthanasia (where legal)

• Addiction potential, both physical and psychological