Definition of "Benzodiazepine"

Last modified: about 1 hour



Benzodiazepine is a depressant drug, used to Tx anxiety, insomnia, agitation, seizure, muscle spasm, alcohol withdrawal, and premedication for medical or dental procedures. They can be either short, intermediate, or long acting.

MOA
  • Enhances the effect of the neurotransmitter GABA, at the GABA-A receptor, resulting in sedative, sleep-inducing, anti-anxiety, anticonvulsant, and muscle relaxant properties
Side effects
  • Cognitive impairments and paradoxical effects (aggression or behavioral disinhibition) occassionally occur. Long term use may cause adverse psychological and physical effects
  • It is prone to cause tolerance, physical dependence, and upon cessation after long term use, withdrawal
  • There is also controversy regarding safety of benzo in pregnancy, and may cause cleft palate
  • They are much less toxic than their predecessor, barbiturates, and death rarely results when benzo is the only drug taken, however, can be toxic and cause fatal overdise when taken with other depressants like ethanol and opiates

Examples of a short-acting benzo is:

  • Brotizolam
  • Midazolam
  • Triazolam

Example of an intermediate-acting benzo is:

  • Alprazolam
  • Estazolam
  • Flunitrazepam
  • Clonazepam


Source: 2014/11/buyclonazepam.jpg">FastRelief4U

  • Lormetazepam
  • Lorazepam
  • Nitrazepam
  • Temazepam

Example of a long-acting benzo is:

  • Diazepam (Valium)


Source: 2015/02/buy-valium-online1.jpg">NHS Clinical scientists

  • Clorazepate
  • Chlordiazepoxide
  • Flurazepam
See also
  • Antidepressant (antonym)

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Definition of Benzodiazepine | Autoprac


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