Autoimmune disease is damage or a pathologic state arising from an abnormal immune response of the body against substances and tissues normally present in the body. Autoimmunity is presence of self-reactive immune responses (e.g. auto-antibodies, self-reactive T cells), with or WITHOUT damage/pathology resulting from it.

• It can be restricted to certain organs (e.g. in autoimmune thyroitiditis), or involve a particular tissue in different places (e.g. Goodpasture's disease, which may affect the basement membrane in both the lung and kidney)

• Heart:
  • Myocarditis
  • Postmyocardial infarction syndrome
  • Postpericardiotomy syndrome
  • Subacute bacterial endocarditis
• Kidney:
  • Anti-glomerular basement membrane nephritis
  • Interstitial cystitis
  • Lupus nephritis
• Liver:
  • Autoimmune hepatitis
  • Primary biliary cirrhosis
  • Primary sclerosing cholangitis
• Lung:
  • Antisynthetase syndrome
• Skin:
  • Alopecia areata
  • Autoimmune angioedema
  • Autoimmune progesterone dermatitis
  • Autoimmune urticaria
  • Bullous pemphigoid
  • Cicatricial pemphigoid
  • Dermatitis herpetiformis
  • Discoid lupus erythematosus
  • Epidermolysis bullosa acquisita
  • Erythema nodosum
  • Gestational pemphigoid
  • Hidradenitis suppurativa
  • Lichen planus
  • Lichen sclerosus
  • Linear IgA disease
  • Morphea
  • Pemphigus vulgaris
  • Pityriasis lichenoides et varioliformis acuta
  • Mucha-Habermann disease
  • Psoriasis
  • Systemic scleroderma
  • Vitiligo
• Adrenal gland:
  • Addison's disease
• Multi-glandular:
  • Autoimmune polyendocrine syndrome
  • Autoimmune polyendocrine syndrome type 3
  • Autoimmune polyendocrine syndrome type 3
• Pancreas:
  • Autoimmune pancreatitis
  • Diabetes mellitus type 1
• Thyroid gland:
  • Autoimmune thyroiditis
  • Ord's thyroiditis
  • Graves' disease
• Reproductive organs:
  • Autoimune oophoritis
  • Endometriosis
  • Autoimmune orchitis
• Salivary glands:
  • Sjogren's syndrome
• Digestive system:
  • Autoimmune enteropathy
  • Celiac disease
  • Crohn's disease
  • Microscopic colitis
  • Ulcerative colitis
• Blood:
  • Antiphospholipid syndrome
  • Aplastic anemia
  • Autoimmune hemolytic anemia
  • Automimune lymphoproliferative syndrome
  • Autoimmune neutropenia
  • Autoimmune thrombocytopenic purpura
  • Cold agglutinin disease
  • Essential mixed cryoglobulinemia
  • Evans syndrome
  • IgG4-related systemic disease
  • Paroxysmal nocturnal hemoglobinuria
  • Pernicious anemia
  • Pure red cell aplasia
  • Thrombocytopenia
• Connective tissue, systemic, and multi-organ:
  • Adiposis dolorosa
  • Adult-onset Still's disease
  • Ankylosing spondylitis
  • CREST syndrome
  • Drug-induced lupus
  • Enthesitis-related arthritis
  • Eosinophilic fasciitis
  • Felty syndrome
  • Juvenile arthritis
  • Lyme disease (chronic)
  • Mixed connective tissue disease
  • Palindromic rheumatism
  • Parry Romberg syndrome
  • Parsonage-Turner syndrome
  • Psoriatic arthritis
  • Reactive arthritis
  • Relapsing polychondritis
  • Retroperitoneal fibrosis
  • Rheumatic fever
  • Rheumatoid arthritis
  • Sarcoidosis
  • Schnitzler syndrome
  • Systemic lupus erythematosus
  • Undifferentiated connective tissue disease
• Muscle:
  • Dermatomyositis
  • Fibromyalgia
  • Inclusion body myositis
  • Myositis
  • Myasthenia gravis
  • Neuromyotonia
  • Paraneoplastic cerebellar degeneration
  • Polymyositis
• Nervous system:
  • Acute disseminated encephalomyelitis
  • Acute motor axonal neuropathy
  • Anti-N-Methyl-D-Aspartate receptor encephalitis
  • Balo concentric sclerosis
  • Bickerstaff's encephalitis
  • Chronic inflammatory demyelinating polyneuropathy
  • Guillain-Barre syndrome
  • Hashimoto's encephalopathy
  • Idiopathic inflammatory demyelinating diseases
  • Lambert-Eaton myasthenic syndrome
  • Multiple sclerosis, pattern 2
  • Pediatric autoimmune neuropsychiatric disorder associated with streptococcus
  • Progressive inflammatory neuropathy
  • Restles leg syndrome
  • Stiff person syndrome
  • Sydenham chorea
  • Transverse myelitis
• Eyes:
  • Autoimmune retinopathy
  • Autoimmune uveitis
  • Cogan syndrome
  • Graves ophthalmopathy
  • Intermediated uveitis
  • Ligneous conjunctivitis
  • Mooren's ulcer
  • Neuromyelitis optica
  • Opsoclonus myoclonus syndrome
  • Optic neuritis
  • Slceritis
  • Susac's syndrome
  • Sympathetic ophthalmia
  • Tolosa-Hunt syndrome
• Ears:
  • Autoimmune inner ear disease
  • Meniere's disease
• Vascular system:
  • Anti-neutrophil cystoplasmic antibody-associated vasculitis
  • Behcet's disease
  • Churg-Strauss syndrome
  • Giant cell arteritis
  • Henoch-Schonlein purpura
  • Kawasaki's disease
  • Leukocytoclastic vasculitis
  • Lupus vasculitis
  • Rheumatoid vasculitis
  • Microscopic polyangiitis
  • Polyarteritis nodosa
  • Polymyalgia rheumatica
  • Urticarial vasculitis
  • Vasculitis

• Immunosuppression, a Rx that decreases the immune response
• Cytokine blockade, or the blockade of cytokine signalling pathways
• Removal of effector T-cells or B-cells, e.g. anti-CD20 therapy can be effective at removing instigating B cells
• IV immunoglobulin, has been helpful to Tx some antibody mediated autoimmune diseases as well, possibly through negative feedback mechanisms

• A large number of autoimmune diseases are recognized